WHEN TO GO:
Forecasts and the Moon
There are surprisingly few times when all the conditions come together for a day of grouper fishing. Foremost are safe conditions. If the seas are forecast to be over 2' it is likely too rough to make the 20mi+ run to the fishing grounds. Thunder storms can change sea conditions in minutes. Make sure you monitor the forecast closely the evening before the trip.
A useful piece of equipment is satellite weather. Compatible with most new fish finders, satellite weather enables monitoring of radar and weather conditions at your location as current as 20min. XM or Sirius weather is one of the best safety values around. It is worth a look.
Assuming the seas and weather ar a go, make sure grouper are in season (see rules and regulations).
One time to avoid is when there is a nearly full moon during the evening hours. The fish seem to stop biting during these times. This is possibly because the fish can feed all night.
For a totally different experience, try night fishing. Leave the dock in the early afternoon and find a promising spot to anchor on before dark. For this type of fishing, a full moon is desirable. Night fishing is known for snapper.
NEXT: FINDING THE FISH